Magnesium L-threonate

Product Characteristics:

Magnesium L-threonate is a specialized form of magnesium designed to optimize its uptake in the brain. Magnesium is an essential mineralthat plays a crucial role in multiple body functions. It is also known to be involved in maintaining cognitive functions such as learning and memory. Due to the unique molecular structure of L-threonate(a derivative of suconosyate), it is thought to be more easily absorbed by the brain. Studies performed in animal models have demonstrated favorable cognitive effects of Magnesium L-threonate. Furthermore, Magnesium L-threonate can help the body relax.

Mg (2 +) is an essential ion in the body and has many essential physiological functions. More than 300 enzymes contain Mg (2 +), which are usually associated with the functions of the cardiovascular, neuromuscular and nervous systems.The study found that only Magnesium L-threonate this form of magnesium, can strongly cross the blood-brain barrier, other forms (other magnesium salts, free magnesium ions, etc.) magnesium is difficult to cross the blood-brain barrier, and it is also the highest absorption rate of magnesium ion compound, absorption rate of up to 70%. Thus, Magnesium L-threonate is more effective than the conventional magnesium supplements (magnesium carbonate, magnesium sulfate, magnesium glycine, etc.).

The magnesium, can at least assist the synthesis of monoamines with GABA and reinforce neuroplasticity, reinforcing the NMDA receptor NR 2 B subunit expression in hippocampal neurons. Monoamines refer to serotonin (serotonin), epinephrine, ororenin (norepinephrine), dopamine, etc.

The mechanism of BBB breakthrough by magnesium suconate and the upregulation of NMDA receptor-mediated signaling underlies enhanced synaptic plasticity. Improvements in mitochondrial function both enhances synaptic protein transport and reduces amyloid- β -mediated deposition by BACE-1.Due to the existence of the blood-brain barrier, it is difficult for common magnesium elements or magnesium compounds to enter the brain directly, so the difficulty is how to effectively improve the brain magnesium level. Therefore, Mg2 + ingestion into the brain through specialized biological processes.

Technical Data(Executive Standard USP41)

Applications:

1. Improved the migraine headache

Magnesium L-threonate can act as an NMDA receptor antagonist with a significant role in the relief of pain. It relaxes pain-causing brain blood vessels and passes through the cell membrane, including the mitochondria, in something that other magnesium supplements cannot do. In neurons, magnesium plays a role in balancing the flow of calcium ions.Magnesium ions regulate migraine through the following mechanisms: 1. Assist in ATP synthesis, 2. regulate neuronal excitability; 3. Maintain vascular tone.

2. Improve the menopausal syndrome

The underlying cause of the development of menopausal syndrome is ovarian failure due to physiological or pathological failure or surgery. Once ovarian function fails or is removed and destroyed, the estrogen secreted by the ovary is reduced.Female body has more than 400 kinds of estrogen receptor, distributed in almost all tissues and organs, accept the control and control of estrogen, once estrogen reduced, can cause degenerative changes in organs and tissues, a series of symptoms, hypothalamic neurotransmitter opioid peptide (EOP), adrenaline (NE), dopamine (DA) has obvious correlation with the occurrence of hot flashes, serotonin (5-HT) to endocrine, cardiovascular, emotional and sexual life have regulating function,At the same time, genetic factors and advanced neurological activities (personality characteristics, neurological type, cultural level, occupation, social and interpersonal relationship, family background, etc.) are also closely related to the onset of menopausal syndrome and the severity of symptoms.

3.The supplementation with Magnesium L-threonate increases vivo magnesium concentrations, which, as a natural antagonist of NMDA and an agonist of GABA, can help regulate the human nervous system. Magnesium can reduce the excitability of NMDA and increase the activity of GABA (γ -aminobutyric acid) receptors. The increase in GABA receptor activity will control the activity of NMDA receptors, which can slow down many menopausal symptoms and help people feel soothing, improve sleep, improve mood swings and hot flashes.

4.Improve sleep quality

Magnesium L-threonate supplementation significantly decreased serum cortisol concentration, which then improves sleep quality, in addition, by supplementing the magnesium ions increased by Magnesium L-threonate, can enhance the γ -aminobutyric acid induced current, affect the function of γ -aminobutyrate type A receptor through a positive allosteric regulation mechanism,However, γ -aminobutyric acid is an important amino acid neurotransmitter in the mammalian central nervous system, which has an inhibitory effect on neuronal activities and has a physiological function to promote sleep. Thus, magnesium, as a natural antagonist of NMDA and an agonist of GABA, plays a critical role in sleep regulation.

5.Improve learning and memory, improve cognition

Studies show that synaptic connections in the brain hippocampus are key brain regions for learning and memory, corresponding to function decline with aging. The study also found lower magnesium in the brains of Alzheimer's disease. NMDA receptor channels are a class of ligand voltage-gated channels. In addition to glutamate and glycine binding to specific sites, NMDA receptor function requires the regulation of zinc ions, D-Serine and polyamines.As a cofactor of Serine racemase, magnesium ion can improve the conversion capacity from L- -Serine to D-Serine by 5 to 10 times. Therefore, thesupplementation of magnesium ions can promote the strengthening of NMDA receptor function and enhance the response ability of NMDA receptor itself: such as the channel opening time is prolonged, the opening frequency of NMDA receptor channel is increased, and the signaling efficiency is improved.Thus, Magnesium L-threonate supplementation improves synaptic plasticity and NMDA (N-methyl-D-aspartate) receptor-dependent signaling to enhance hippocampus function, and the MIT researchers concluded that using L-threonate to increase brain magnesium levels is beneficial for enhancing learning cognition and memory.

6.Reduce stress and feel better

ThroughMagnesium L-threonate, increasing the brain magnesium content can promote the elimination of fear memory and stabilize emotions without enhancing the amygdala-dependent fear memory. Magnesium is essential for the normal function of neurotransmitters, including serotonin, dopamine, and γ -aminobutyric acid (GABA). Magnesium improves serotonin levels in our brains, helping with a balance of blood sugar and stabilizing our emotions.

7.Improve ADHD

Magnesium L-threonate is a magnesium-containing electrolyte supplement that regulates neuromuscular excitability, is commonly used in the treatment of diseases such as calcium deficiency and ADHD, and has certain benefits for children with attention deficit hyperactivity disorder. Magnesium ion has the effect of inhibiting the central nervous system, can play a sedative effect, to relieve the symptoms of patients with ADHD irritability, irritability, impulsive behavior and other symptoms have certain help.

Packaging and storage:

This product is packaged in paper barrel, 25kg per barrel, and can also be customized according to user requirements. It should be sealed and stored in a cool, dry place away from light, with a shelf life of twenty-four months.

Safety Protection

This product should avoid contact with the eyes, skin or clothes, once splashed on the body, should be immediately washed with a lot of water.